氧化苏木精
HEMATEIN
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分子式 :
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基础信息
| 中文名称 | 氧化苏木精 |
|---|---|
| 英文名称 | HEMATEIN |
| 别名 | 苏木因 | 苏木红 | 海尔丹 | 天然黑1 | 氧化苏木素 | 氧化苏木精 | 氧化苏木红 |
| Cas No. | 475-25-2 |
| 精确分子量 | 300.06339 |
| Smiles | C1C2=CC(=C(C=C2C2=C3C=CC(=O)C(O)=C3OCC12O)O)O |
安全信息
| 密度 | 1.2766 (rough estimate) |
|---|---|
| 熔点 | 180 °C |
| 沸点 | 361.5°C |
| 运输要求 | 常温运输 |
| 海关编码 | 32030010 |
| 特性 | * |
| 安全说明(旧) | 24/25 |
| 水溶解性 | 0.6g/L(20 ºC) |
| 存储要求 | 2-8°C |
| 闪点 | 289 °C |
产品详情
生物活性
Hematein 是苏木精的氧化产物，可作为染料。Hematein 是一种变构酪蛋白激酶 II 抑制剂，IC50 为 0.74 μM。Hematein 抑制 Akt/PKB Ser129 磷酸化，Wnt/TCF 途径并增加肺癌细胞的凋亡。
靶点
CKII 0.74 μM (IC 50) | Akt | Wnt |
体外研究
Hematein (10-100 μM; 14 days) inhibits cells growth in A427 lung cancer cells.
Hematein (50 and 100 μM; 48 hours) induces apoptosis in A427 lung cancer cells.
Hematein (50 and 100 μM; 48 hours) inhibits CK2-specific Akt phosphorylation.
Cell Viability Assay
| Cell Line: | A427 (HTB-53) cell line |
| Concentration: | 10-100 μM |
| Incubation Time: | 14 days |
| Result: | Inhibited cells growth. |
Apoptosis Analysis
| Cell Line: | A427 (HTB-53) cell line |
| Concentration: | 50 and 100 μM |
| Incubation Time: | 48 hours |
| Result: | Induced apoptosis in A427 lung cancer cells. |
Western Blot Analysis
| Cell Line: | A427 (HTB-53) cell line |
| Concentration: | 50 and 100 μM |
| Incubation Time: | 48 hours |
| Result: | Inhibited CK2-specific Akt phosphorylation. |
体内研究
Hematein (intraperitoneal injections; 50 mg/kg; twice a week for 6 weeks) inhibits tumor growth in A427 lung cancer cell xenografts.
| Animal Model: | Female athymic BALB/c nude mice (6-week-old) |
| Dosage: | 50 mg/kg |
| Administration: | Intraperitoneal injections; twice a week for 6 weeks |
| Result: | Inhibited tumor growth in A427 lung cancer cell xenografts. |
