4,6-亚乙基-alpha-D-葡萄糖
4,6-O-Ethylidene-alpha-D-glucose
| 货号 | 包装规格 | 纯度/级别 | 交货周期 | 价格 | 数量 |
|---|---|---|---|---|---|
| YB10265-200mg | 200mg | 96% | 现货 | ||
| YB10265-1g | 1g | 96% | 现货 | ||
| YB10265-5g | 5g | 96% | 现货 | ||
| YB10265-25g | 25g | 96% | 现货 |
| 中文名称 | 4,6-亚乙基-alpha-D-葡萄糖 |
|---|---|
| 英文名称 | 4,6-O-Ethylidene-alpha-D-glucose |
| 别名 | 4,6-亚乙基-Α-D-葡萄糖;4,6-O-亚乙基-Α-D-吡喃葡萄糖;4,6-O-亚乙基-Α4,6-O-亚乙基-Α-D-吡喃葡Chemicalbook糖;4,6-O-亚乙基-Α-D-葡糖;4,6-O-亚乙基-Α-D-葡萄糖;4,6-亚乙基-alpha-D-葡萄糖;460-乙缩醛-D-葡萄糖 |
| Cas No. | 13224-99-2 |
| MDL No. | MFCD00006820 |
| 精确分子量 | 206.07904 |
| Smiles | CC1OC[C@@H]2[C@H]([C@@H]([C@H]([C@H](O2)O)O)O)O1 |
| 密度 | 1.4±0.1 g/cm3 |
|---|---|
| 危险类别(旧) | R36/37/38 |
| 熔点 | 168-170ºC |
| 沸点 | 386.6±42.0 °C |
| 海关编码 | 29400090 |
| 特性 | * |
| 安全说明(旧) | S36/37/39 |
| 水溶解性 | 微溶 |
| 存储要求 | 密封，室温，干燥 |
| 闪点 | >110°(230°F) |
生物活性
4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose) 是一种葡萄糖衍生物，是竞争性的葡萄糖转运蛋白 1 (GLUT1) 面部结合部位抑制剂，对野生型 2-脱氧-D-葡萄糖转运的 Ki 值为 12 mM。
靶点
GLUT1 | Human Endogenous Metabolite |
体外研究
4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose) shows poor affinity for malarial hexose transporter (PfHT1; K
i
>50 mM). 4,6-O-ethylidene-α-D-glucose inhibits wild-type transport with a K
i
of approximately 12 mM, but this is increased to greater than 120 mM in the Gln282-Leu mutant.
4,6-O-ethylidene-α-D-glucose inhibits glucose exit competitively but its penetration into human red cells is unaffected by glucose in the medium. The potentiation of the development of FDNB inhibition by sugars in the incubating medium is absent when 4,6-O-ethylidene-α-D-glucose is used and there is a slight protective action. 4,6-O-ethylidene-α-D-glucose penetrates human red cells by simple diffusion supported by its penetration of guinea-pig red cells at similar rates, by the occurrence of osmotic haemolysis in isosmotic solutions which is unaffected by copper ions and by the relatively high ether/water partition of the compound.
