薁磺酸钠
Sodium gualenate
| 货号 | 包装规格 | 纯度/级别 | 交货周期 | 价格 | 数量 |
|---|---|---|---|---|---|
| YB42402-1g | 1g | 98% | 现货 | ||
| YB42402-5g | 5g | 98% | 现货 | ||
| YB42402-25g | 25g | 98% | 现货 | ||
| YB42402-100g | 100g | 98% | 现货 |
| 中文名称 | 薁磺酸钠 |
|---|---|
| 英文名称 | Sodium gualenate |
| 别名 | 薁磺酸钠 呱仑酸钠 |
| Cas No. | 6223-35-4 |
| MDL No. | MFCD00866167 |
| 精确分子量 | 300.07961 |
| Smiles | CC1C=CC(C(C)C)=CC2C=1C(S([O-])(=O)=O)=CC=2C.[Na+] |
| 信号词 | Warning |
|---|---|
| 危险类别(旧) | R36/37/38 |
| 熔点 | 98 °C |
| 沸点 | 98°C(lit.) |
| 运输要求 | 低温冰袋运输 |
| 海关编码 | 2904100000 |
| 特性 | * |
| 安全说明(旧) | S36/37/39 |
| 水溶解性 | DMSO : 30 mg/mL (99.88 mM) |
| 符号 | GHS07 |
| 存储要求 | 存储于阴凉干燥处,密封.长期存放建议冷藏(4°C以下),充氮 |
薁磺酸钠不稳定，受光照，空气氧化和高温环境下会分解，易脱去磺酸基。根据现有报道，薁磺酸钠含有半个或一个结晶水均是常见情况。
应用
薁磺酸钠是洋甘菊花的有效成分，具有很强的抗胃蛋白酶、消炎、抗菌、抗过敏、促进粘膜新城代谢的作用，主要用于研究十二指肠溃疡，胃溃疡和胃炎。
作用机制
薁磺酸钠通过局部直接作用抑制炎性细胞释放组胺；增加粘膜内前列腺素E2的合成，促进肉芽形成和上皮细胞新生；并能降低胃蛋白酶的活性。
生物活性
Sodium gualenate (Guaiazulenesulfonate sodium) 是桂皮烯的亲水性衍生物，具有优良的抗炎和愈伤作用，主要用于研究十二指肠溃疡，胃溃疡和胃炎。
体外研究
Sodium gualenate is an unstable compound, which is gradually decomposed in the solid state at room temperature. When heated, Sodium gualenate decomposes almost completely within 1 week. It was found that a kneaded mixture of Sodium gualenate and cornstarch (weight ratio; 1:250) for tableting with water is stable. So, during production, Sodium gualenate could be stabilized using water. Sodium gualenate slightly inhibits the histamine release from rat peritoneal mast cells and strongly inhibits the leukocyte emigration induced by fMLP.
体内研究
Sodium gualenate has been frequently used for the treatment of human gastritis. Cytoprotection is defined as the main mechanism of Sodium gualenate to protect the mucosa of the stomach and the antipeptic actions in vivo have also been shown.
